Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders.

@article{Knapman2010IncreasedSR,
  title={Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders.},
  author={Alana Knapman and J-M Heinzmann and Rainer Hellweg and Florian Holsboer and Rainer Landgraf and Chadi Touma},
  journal={Journal of psychiatric research},
  year={2010},
  volume={44 9},
  pages={566-75}
}
Cognitive deficits are a common feature of major depression (MD), with largely unknown biological underpinnings. In addition to the affective and cognitive symptoms of MD, a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is commonly observed in these patients. Increased plasma glucocorticoid levels are known to render the hippocampus susceptible to neuronal damage. This structure is important for learning and memory, creating a potential link between HPA axis dysregulation and… CONTINUE READING