Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression.

@article{Wegener2010IncreasedSN,
  title={Increased stress-evoked nitric oxide signalling in the Flinders sensitive line (FSL) rat: a genetic animal model of depression.},
  author={Gregers Wegener and Brian Herbert Harvey and Birgit Egeskov Bonefeld and Heidi Kaastrup M{\"u}ller and Vallo Volke and David H. Overstreet and Betina Elfving},
  journal={The international journal of neuropsychopharmacology},
  year={2010},
  volume={13 4},
  pages={461-73}
}
Stress engenders the precipitation and progression of affective disorders, while stress-related release of excitatory mediators is implicated in the degenerative pathology observed especially in the hippocampus of patients with severe depression. Nitric oxide (NO) release following stress-evoked N-methyl-d-aspartate (NMDA) receptor activation modulates neurotransmission, cellular memory and neuronal toxicity. We have investigated the Flinders rat (FSL/FRL), a genetic animal model of depression… CONTINUE READING
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