Increased stratum corneum turnover induced by subclinical irritant dermatitis

@article{Wilhelm1990IncreasedSC,
  title={Increased stratum corneum turnover induced by subclinical irritant dermatitis},
  author={Klaus-Peter Wilhelm and J G C Saunders and Howard I Maibach},
  journal={British Journal of Dermatology},
  year={1990},
  volume={122}
}
The chronic effects of the irritant sodium lauryl sulphate (SLS) on stratum corneum (SC) barrier function, determined by transepidermal water loss (TEWL) measurements and on epidermal cell kinetics, estimated by stratum corneum turnover time (SCTT) determination (dansyl chloride staining method), were investigated in 18 healthy female volunteers. SLS (7·5%) was applied without occlusion for 20 min once daily, over a period of 3 weeks (5 days a week) on dansyl chloride‐stained skin and on… 

Effects of calcipotriol on stratum corneum barrier function, hydration and cell renewal in humans

TLDR
Compared with the skin irritation induced by SLS, under these test conditions, calcipotriol is a far weaker irritant on normal human skin and accelerates stratum corneum turnover to a significantly greater extent than its vehicle.

Study of cumulative irritant contact dermatitis in man utilizing open application on subclinically irritated skin

TLDR
Impaired skin barrier function, elicited by subclinical irritation from short‐duration contact with some irritants, might augment the cumulative irritant contact dermatitis caused by repeated open exposure to other surfactants.

Differential irritant skin responses to topical retinoic acid and sodium lauryl sulphate: alone and in crossover design

TLDR
The irritant effects of 0·05% and 0·1% RA in ethanol on normal skin compared with 1% sodium lauryl sulphate (SLS) in water as a model irritant in a 24‐h occlusive patch‐test assay is quantified.

SLS-irritated human skin shows no correlation between degree of proliferation and TEWL increase

TLDR
The results suggest that epidermal proliferation is modulated by a direct interaction of the surfactant with the keratinocytes and/or by release of mediators rather than the consequence of a barrier disturbance.

The influence of daily dish‐washing with synthetic detergent on human skin

Summary The effects of regular dish‐washing on the stratum corneum barrier function, as determined by transepidermal water loss (TEWL), and objective and subjective skin parameters, were investigated

Effect of sodium lauryl sulfate-induced skin irritation on in vitro percutaneous absorption of four drugs.

TLDR
Percutaneous penetration parameters were equivocally influenced by SLS-induced irritation, and increased skin concentrations were paralleled by even higher increases in flux.

Baseline transepidermal water loss in patients with acute and healed irritant contact dermatitis

TLDR
It is assumed, that increased basal TEWL in patients with ICD may relied a constitutional deviation of epidermal barrier function, and seems to be comparable with the well‐known symptom of atopic individuals.

The influence of daily dish-washing with synthetic detergent on human skin.

TLDR
It is concluded that regular exposure to low concentrations of detergents as used for dish-washing is capable of inducing skin lesions in a substantial proportion of individuals.

The influence of hard water (calcium) and surfactants on irritant contact dermatitis

TLDR
Investigation of differences in surfactant‐induced irritant skin reactions from cumulative exposure to 3 different personal cleansing agents found the hardness of the rinse water to be the more significant factor, versus that of the wash water.

References

SHOWING 1-10 OF 24 REFERENCES

Prediction of susceptibility to an irritant response by transepidermal water loss

TLDR
Baseline TEWL may be used as a reasonably accurate preliminary “predictive” screening test for susceptibility to irritants and multiple linear regression analysis of results indicated that a high baseline TewL is a better indication of an individual's increased susceptibility to weak irritants than a high TEWl value following a single 24‐h patch test.

Sodium – lauryl – sulphate – induced cutaneous irritation

TLDR
TEWL and WC responses showed a greater sensitivity in hispanics possibly reflecting a different modulation of the water burner function after chemical exposure, and the microcirculatory response, as long as detected with LDV, was similar in the 2 groups.

Effect of Nonvisible Damage on the Water-Holding Capacity of the Stratum Corneum, Utilizing the Plastic Occlusion Stress Test (POST)

Skin surface water loss (SSWL) was studied after plastic occlusion stress test (POST) in visually non-damaged skin treated with sodium laurylsulfate for 3 days. SSWL decay curves and decay constants

Skin irritancy of surfactants as assessed by water vapor loss measurements.

TLDR
The reactions of the tested subjects to the surfactants suggest that each individual has his own pattern of susceptibility to these substances.

REGENERATIVE PROLIFERATION OF MOUSE EPIDERMAL CELLS FOLLOWING APPLICATION OF A SKIN IRRITANT (CANTHARIDIN)

The strong skin irritant cantharidin dissolved in benzene was applied to the back of hairless mice. Single cell suspensions of epidermal basal cells were obtained and flow microfluorometric

The dansyl chloride technique for stratum corneum renewal as an indicator of changes in epidermal mitotic activity following topical treatment

TLDR
The relationship between epidermal mitotic activity and stratum corneum renewal time of topically treated skin as determined by the dansyl chloride staining technique is investigated using a hypomitotic agent and hypermitotic agent.

The use of transepidermal water loss to measure and predict the irritation response to surfactants

TLDR
A high baseline TEWL value may be predictive of a high susceptibility to soap irritation as measured by the chamber test, and there was also a statistically significant correlation between TewL values obtained on the untreated skin at Time 0 and the five‐day average irritation score for these two cleansing products.

Improved fluorescence staining technique for estimating turnover of the human stratum corneum

The replacement time of the human stratum corneum of fifteen body regions was determined by measuring the days required for a strongly substantive fluorescent marker, Dansyl chloride, to disappear.

A fluorescence photographic photometric technique to assess stratum corneum turnover rate and barrier function in vivo

A photographic photometric method for objective measurement of fluorescence in skin is described. This method has been used to (a) improve the dansyl chloride method for determining stratum corneum