Increased stratum corneum turnover induced by subclinical irritant dermatitis

  title={Increased stratum corneum turnover induced by subclinical irritant dermatitis},
  author={Klaus-Peter Wilhelm and J G C Saunders and Howard I Maibach},
  journal={British Journal of Dermatology},
The chronic effects of the irritant sodium lauryl sulphate (SLS) on stratum corneum (SC) barrier function, determined by transepidermal water loss (TEWL) measurements and on epidermal cell kinetics, estimated by stratum corneum turnover time (SCTT) determination (dansyl chloride staining method), were investigated in 18 healthy female volunteers. SLS (7·5%) was applied without occlusion for 20 min once daily, over a period of 3 weeks (5 days a week) on dansyl chloride‐stained skin and on… 

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The reactions of the tested subjects to the surfactants suggest that each individual has his own pattern of susceptibility to these substances.


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