Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis.

  title={Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis.},
  author={Penelope C. Georges and Jia Ji Hui and Zolt{\'a}n Gombos and Margaret E. McCormick and Andrew Y. Wang and Masayuki Uemura and Rosemarie Mick and Paul A. Janmey and Emma Elizabeth Furth and Rebecca G. Wells},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={293 6},
Liver fibrosis, the response to chronic liver injury, results from the activation of mesenchymal cells to fibrogenic myofibroblasts. We have recently shown that two key myofibroblast precursor populations, hepatic stellate cells and portal fibroblasts, undergo activation in culture in response to increasing substrate stiffness. We therefore hypothesized that alterations in liver stiffness precede myofibroblast activation and fibrosis in vivo as well. To test this hypothesis, we induced fibrosis… 

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