Increased spinal monoamine concentrations after chronic thoracic dorsal rhizotomy in goats.

  title={Increased spinal monoamine concentrations after chronic thoracic dorsal rhizotomy in goats.},
  author={G. Mitchell and K. B. Bach and P. A. Mart{\'i}n and K. Foley and E. Olson and M. Brownfield and V. Mileti{\'c} and M. Behan and S. Mcguirk and H. E. Sloan},
  journal={Journal of applied physiology},
  volume={89 4},
In goats, bilateral thoracic dorsal rhizotomy (TDR) causes severe ventilatory failure during exercise, followed by progressive functional recovery. We investigated spinal neurochemical changes associated with TDR and/or functional recovery by measuring spinal concentrations of the monoamines serotonin (5-HT), norepinephrine, and dopamine via HPLC. Changes in 5-HT and calcitonin gene-related peptide were visualized with immunohistochemistry. Goat spinal cords were compared 4-15 mo after TDR from… Expand
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