Increased spinal dynorphin levels and phospho-extracellular signal-regulated kinases 1 and 2 and c-Fos immunoreactivity after surgery under remifentanil anesthesia in mice.

@article{Campillo2010IncreasedSD,
  title={Increased spinal dynorphin levels and phospho-extracellular signal-regulated kinases 1 and 2 and c-Fos immunoreactivity after surgery under remifentanil anesthesia in mice.},
  author={Ana Campillo and Ana Gonz{\'a}lez-Cuello and David Caba{\~n}ero and Paula Garc{\'i}a-Nogales and Asunci{\'o}n Blanco Romero and Mar{\'i}a Victoria Milan{\'e}s and Mar{\'i}a Luisa Laorden and Margarita Mar{\'i}a Puig},
  journal={Molecular pharmacology},
  year={2010},
  volume={77 2},
  pages={
          185-94
        }
}
In humans, remifentanil anesthesia enhances nociceptive sensitization in the postoperative period. We hypothesized that activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and the expression of c-Fos, prodynorphin (mRNA), and dynorphin in the spinal cord could participate in the molecular mechanisms underlying postoperative opioid-induced sensitization. In a mouse model of incisional pain, we evaluated thermal (Hargreaves test) and mechanical (von Frey) hyperalgesia during the… CONTINUE READING

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