Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis.

@article{Greisen2014IncreasedSP,
  title={Increased soluble programmed death-1 (sPD-1) is associated with disease activity and radiographic progression in early rheumatoid arthritis.},
  author={Stinne Ravn Greisen and Tue Kruse Rasmussen and Kristian Stengaard-Pedersen and Merete Lund Hetland and Kim H\orslev-Petersen and Malene Hvid and Bent Deleuran},
  journal={Scandinavian journal of rheumatology},
  year={2014},
  volume={43 2},
  pages={101-8}
}
OBJECTIVES Programmed death-1 (PD-1) is an immunoregulatory molecule functioning by down-regulating immune responses. PD-1 is present on follicular helper T cells (TFH) and is important in the formation of plasma cells. PD-1 exists in a bioactive soluble form (sPD-1) and is thought to be implicated in disease activity in chronic rheumatoid arthritis (RA). METHOD We measured sPD-1 at baseline and 9 months after treatment initiation in plasma from early RA patients (n = 34). We tested for… CONTINUE READING