Increased soluble CD40L levels are reduced by long-term simvastatin treatment in peritoneally dialyzed patients.

@article{Malyszko2004IncreasedSC,
  title={Increased soluble CD40L levels are reduced by long-term simvastatin treatment in peritoneally dialyzed patients.},
  author={Jolanta Malyszko and Jacek Malyszko and Tomasz Hryszko and Michal C Myśliwiec},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2004},
  volume={15 6},
  pages={
          463-7
        }
}
BACKGROUND Dyslipidemia and increased mortality due to cardiovascular events are common in peritoneally dialyzed patients [continuous ambulatory peritoneal dialysis (CAPD)]. Statins show beneficial effects on serum lipids and reduce cardiovascular mortality. The CD40-CD40 ligand (CD40L) system has proved critical for the activation of tissue structural cells that include endothelial cells, epithelial cells and fibroblasts. It has been reported that enhanced CD40L-CD40 interaction in familial… CONTINUE READING