Increased sheep lung vascular permeability caused by Escherichia coli endotoxin.

@article{Brigham1979IncreasedSL,
  title={Increased sheep lung vascular permeability caused by Escherichia coli endotoxin.},
  author={Kenneth L. Brigham and R. Bowers and J. Haynes},
  journal={Circulation research},
  year={1979},
  volume={45 2},
  pages={292-7}
}
We infused Escherichia coli endotoxin, 0.07-1.33 microgram/kg, intravenously into chronically instrumented unanesthetized sheep and measured pulmonary arterial and left atrial pressures, lung lymph flow, lymph and blood plasma protein concentrations, and arterial blood gases. Endotoxin caused a biphasic reaction: an early phase of pulmonary hypertension and a long late phase of steady state increased pulmonary vascular permeability during which pulmonary arterial and left atrial pressures were… CONTINUE READING
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The inference of pulmonary capillary permeability from multiple indicator data: Effects of increased capillary pressure and alloxan treatment in the dog

  • T Harris, C Woltz, K Brigham
  • Proc 29th Ann Conf Eng Med Biol
  • 1976
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