Increased shear stress leads to differential release of endothelin and ATP from isolated endothelial cells from 4- and 12-month-old male rabbit aorta.

@article{Milner1992IncreasedSS,
  title={Increased shear stress leads to differential release of endothelin and ATP from isolated endothelial cells from 4- and 12-month-old male rabbit aorta.},
  author={P. N. Milner and Philippe Bodin and Andrzej Loesch and Geoffrey Burnstock},
  journal={Journal of vascular research},
  year={1992},
  volume={29 6},
  pages={420-5}
}
Freshly isolated thoracic aortic endothelial cells from 4- and 12-month-old male rabbits were exposed to two periods of increased flow rate and the levels of ATP, endothelin (ET) and arginine vasopressin (AVP) released into the perfusate were measured. The rapid, significant release of ATP and ET with increased flow from cells isolated from 12-month-old rabbits was not seen when cells isolated from 4-month-old rabbits were exposed to the same conditions. Increased flow did not stimulate AVP… CONTINUE READING

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