Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene.

@article{Kalueff2006IncreasedSO,
  title={Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene.},
  author={Allan Kalueff and Anna Minasyan and Tiina Keisala and Marianne Kuuslahti and Susanna Miettinen and Pentti Tuohimaa},
  journal={Neuroscience letters},
  year={2006},
  volume={394 1},
  pages={69-73}
}
Vitamin D is a neuroactive steroid hormone with multiple functions in the brain. Numerous clinical and experimental data link various Vitamin D-related dysfunctions to epilepsy. Here, we study the role of Vitamin D receptors (VDRs) in experimental epilepsy in mice. To examine this problem, we assessed the seizure profiles in VDR knockout mice following a systemic injection of pentylenetetrazole (70 mg/kg). Overall, compared to the wild-type (WT) 129S1 mice (n=10 in each group), the VDR knockout… CONTINUE READING