Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome.

@article{Dlugosz2015IncreasedSL,
  title={Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea-predominant irritable bowel syndrome.},
  author={Aldona Dlugosz and Piotr Nowak and Mauro D'Amato and G Mohammadian Kermani and Jessica Nystr{\"o}m and Samir Abdurahman and Greger Lindberg},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2015},
  volume={27 12},
  pages={1747-54}
}
BACKGROUND Innate immune responses to conserved microbial products such as lipopolysaccharide (LPS) and flagellin are likely important in microbial-host interactions and intestinal homeostasis. We hypothesized that bacterial translocation and activation of mucosal immunity against common microbial antigens might be involved in the development of irritable bowel syndrome (IBS). We therefore compared serum levels of LPS, soluble CD14 (sCD14), and flagellin antibodies between patients with… CONTINUE READING
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