Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma

@article{Wu2012IncreasedSL,
  title={Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma},
  author={Bao-jin Wu and Wen-peng Li and Cheng Qian and Wei Ding and Zhong-wen Zhou and Hua Jiang},
  journal={Tumor Biology},
  year={2012},
  volume={34},
  pages={643-648}
}
Thymidine kinase 1 (TK1) is involved in cancer progression. Metastatic site is a prognostic factor in melanoma. We assessed whether serum levels of TK1 are associated with metastatic sites or prognosis in patients treated for stage IV melanoma. The study included 64 patients, who received dacarbazine or four-drug chemotherapy (dacarbazine, vincristine, bleomycin, and lomustine) both combined with interferon-alfa. Serum samples for TK1 were analyzed by ELISA. The patients (n = 22) with only skin… 

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