Increased serum concentrations of soluble tumor necrosis factor receptors p55 and p75 in early onset neonatal sepsis.

@article{Doellner1998IncreasedSC,
  title={Increased serum concentrations of soluble tumor necrosis factor receptors p55 and p75 in early onset neonatal sepsis.},
  author={H Doellner and K J Arntzen and P E Haereid and S Aag and Ann-Mari Brubakk and Rigmor Austgulen},
  journal={Early human development},
  year={1998},
  volume={52 3},
  pages={
          251-61
        }
}
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The results indicate that TNF either does not play an important role in the appearance of sTNFRs in systemic infection or that a small amount of TNF remaining in the circulation after some bacterial challenges is sufficient to preserve the secretion of its soluble receptors.
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The high concentration of p55 in neonatal urine may reflect a postpartum elimination of soluble receptors shed during pregnancy, and further studies are needed to determine the origin and physiologic implications of the soluble TNF-α receptors in pregnancy.
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