Increased serum concentration of BAFF/APRIL and IgA2 subclass in patients with mixed connective tissue disease complicated by interstitial lung disease.

@article{Kaneko2014IncreasedSC,
  title={Increased serum concentration of BAFF/APRIL and IgA2 subclass in patients with mixed connective tissue disease complicated by interstitial lung disease.},
  author={Toshiyuki Kaneko and Hirofumi Amano and Shinya Kawano and Kentaro Minowa and Seiichiro Ando and Takashi Watanabe and Soichiro Nakano and Jun Suzuki and Shinji Morimoto and Yoshiaki Tokano and Yoshinari Takasaki},
  journal={Modern rheumatology},
  year={2014},
  volume={24 2},
  pages={310-5}
}
B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are known to be crucial for B cell maturation and survival, and increased expression of these factors in various autoimmune diseases has been reported. Human B cells produce two IgA subclasses: IgA1 and IgA2, the latter being abundant in the distal intestine, saliva, colostrum and bronchial fluid. We investigated these parameters in patients with mixed connective tissue disease (MCTD) complicated by interstitial lung… CONTINUE READING