Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients.

@article{Rosell2010IncreasedS2,
  title={Increased serotonin 2A receptor availability in the orbitofrontal cortex of physically aggressive personality disordered patients.},
  author={Daniel R. Rosell and Judy Thompson and Mark Slifstein and Xiaoyan Xu and W. Gordon Frankle and Antonia S. New and Marianne S. Goodman and Shauna R Weinstein and Marc Laruelle and Anissa Abi-Dargham and Larry J. Siever},
  journal={Biological psychiatry},
  year={2010},
  volume={67 12},
  pages={1154-62}
}
BACKGROUND Impulsive physical aggression is a common and problematic feature of many personality disorders. The serotonergic system is known to be involved in the pathophysiology of aggression, and multiple lines of evidence have implicated the serotonin 2A receptor (5-HT(2A)R). We sought to examine the role of the 5-HT(2A)R in impulsive aggression… CONTINUE READING