Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea

@article{Yamasaki2007IncreasedSP,
  title={Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea},
  author={Kenshi Yamasaki and Anna Di Nardo and Antonella Bardan and Masamoto Murakami and Takaaki Ohtake and Alvin B. Coda and Robert A Dorschner and C Bonnart and Pascal Descargues and Alain Hovnanian and Vera B. Morhenn and Richard L. Gallo},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={975-980}
}
Acne rosacea is an inflammatory skin disease that affects 3% of the US population over 30 years of age and is characterized by erythema, papulopustules and telangiectasia. The etiology of this disorder is unknown, although symptoms are exacerbated by factors that trigger innate immune responses, such as the release of cathelicidin antimicrobial peptides. Here we show that individuals with rosacea express abnormally high levels of cathelicidin in their facial skin and that the proteolytically… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to determine the effect of topical aminocaproic acid on the immune system by assessing the levels of antimicrobial peptides in the skin of patients with… Expand
ConditionsRosacea
InterventionDrug
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TLDR
Current knowledge about keratinocyte-derived proteases and protease inhibitors, which might have a role in the pathophysiology of rosacea are summarized. Expand
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It was determined that CC ameliorates the expression of pro-inflammatory cytokines through the inhibition of LL-37 processing and revealed its mechanism of action, indicating that CC may be a useful therapeutic agent for rosacea. Expand
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It is demonstrated that MCs play a central role in the development of inflammation subsequent to Cath LL-37 activation and that down regulation of activated MCs may be a therapy for rosacea treatment. Expand
Increased Expression of Cathelicidin by Direct Activation of Protease-Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea
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PAR-2 may participate in the pathogenesis of rosacea through activation of cathelicidin LL-37, a mediator of innate immune responses in the skin. Expand
Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease
TLDR
In this review, the current evidence on the role of cathelicidin LL-37 in the pathogenesis of inflammatory skin diseases will be outlined and potential novel treatment strategies for those Diseases will be discussed. Expand
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The molecular studies show a common link between the triggers of rosacea and the cellular response, and these observations suggest that an altered innate immune response is involved in disease pathogenesis. Expand
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Anionic polysaccharides, exemplified by SAGEs, offer potential as novel mechanism-based therapies for rosacea and by extension other LL-37-mediated and RAGE-ligand driven skin diseases. Expand
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Evidence is provided that cathelicidin is implicated in NS-associated skin inflammation in vivo and marketed products that are known to reduce cathe Alicidin expression could be repurposed for the management of NS. Expand
[Cathelicidins: multifunctional defense molecules of the skin].
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