Increased sensitivity to the antinociceptive activity of (±)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia

@article{Smith1994IncreasedST,
  title={Increased sensitivity to the antinociceptive activity of (±)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia},
  author={G Smith and Simon M. Harrison and Phillip John Birch and Pamela J. Elliott and Marzia Malcangio and Norman George Bowery},
  journal={Neuropharmacology},
  year={1994},
  volume={33},
  pages={1103-1108}
}
Modulation of sensory afferent inputs to the spinal cord by GABA appears to be an important physiological mechanism and may provide an antinociceptive control system. In the present study we have evaluated the antinociceptive activity of the GABAB receptor agonist, (+/-)-baclofen, in rats with unilateral chronic inflammatory or neuropathic hyperalgesia. (+/-)-Baclofen was antinociceptive in untreated control animals and both animal models. In the neuropathic model the sensitivity to… CONTINUE READING
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