Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation.

@article{Chavko2001IncreasedST,
  title={Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation.},
  author={Mikulas Chavko and Guoqiang Xing and David O. Keyser},
  journal={Brain research},
  year={2001},
  volume={900 2},
  pages={227-33}
}
Nitric oxide is involved in the mechanism of hyperbaric oxygen (HBO(2)) brain toxicity as nitric oxide synthase (NOS) inhibitors delay latent time before the onset of seizures. The purpose of this study was to investigate if seizures affect sensitivity to convulsions during subsequent exposure to HBO(2) and to determine if NOS activity and expression is changed after HBO(2) seizures. Rats were exposed to 5 atm (gauge pressure) 100% O(2) until seizures recorded by electroencephalograph (EEG) and… CONTINUE READING