Increased sensitivity to kindling in mice lacking TSP1.

  title={Increased sensitivity to kindling in mice lacking TSP1.},
  author={Diana Mendus and Elyse K Rankin-Gee and Mirna Mustapha and Brenda E. Porter},
The development of a hyperexcitable neuronal network is thought to be a critical event in epilepsy. Thrombospondins (TSPs) regulate synaptogenesis by binding the neuronal α2δ subunit of the voltage-gated calcium channel. TSPs regulate synapse formation during development and in the mature brain following injury. It is unclear if TSPs are involved in hyperexcitability that contributes to the development of epilepsy. Here we explore the development of epilepsy using a pentylenetetrazole (PTZ… CONTINUE READING
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