Increased sensitivity to epinephrine stimulated lipolysis during starvation: tighter coupling of the adenylate cyclase complex.

@article{Dax1981IncreasedST,
  title={Increased sensitivity to epinephrine stimulated lipolysis during starvation: tighter coupling of the adenylate cyclase complex.},
  author={Elizabeth M. Dax and John S. Partilla and Robert I. Gregerman},
  journal={Biochemical and biophysical research communications},
  year={1981},
  volume={101 4},
  pages={
          1186-92
        }
}
Abstract Adipocytes of rats starved for 72 hr showed three-fold increase in sensitivity of the lipolytic response to epinephrine. Adenylate cyclase sensitivity in adipocyte membranes from starved rats was increased almost seven-fold over control rats. Binding studies using [ 3 H]-dihydroalprenolol showed that the number of β-adrenergic receptors per fat cell (1.1 × 10 5 and 1.1 × 10 5 receptors/cell, starved vs control) and the dissociation constant (5 vs 4 nM) of the receptor for the… CONTINUE READING
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