Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene.

Abstract

The gene PIGA encodes one of the protein subunits of the alpha1-6-N acetylglucosaminyltransferase complex, which catalyses an early step in the biosynthesis of glycosyl phosphatidylinositol (GPI) anchors. PIGA is somatically mutated in blood cells from patients with paroxysmal nocturnal hemoglobinuria (PNH), leading to deficiency of GPI-linked proteins on… (More)

Topics

12 Figures and Tables

Cite this paper

@article{Tremml1999IncreasedST, title={Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene.}, author={Gabi Tremml and C. Dom{\'i}nguez and Valentina D Rosti and Z. Zhang and Paolo P Pandolfi and Peter Michael Keller and Mark Bessler}, journal={Blood}, year={1999}, volume={94 9}, pages={2945-54} }