Increased sensitivity to benzodiazepine antagonists in rats following chronic treatment with a low dose of diazepam

@article{Lucki2005IncreasedST,
  title={Increased sensitivity to benzodiazepine antagonists in rats following chronic treatment with a low dose of diazepam},
  author={Irwin Lucki and Robert F. Kucharik},
  journal={Psychopharmacology},
  year={2005},
  volume={102},
  pages={350-356}
}
The effects of benzodiazepine (BZ) antagonists on operant behavior were examined in rats chronically administered a low dose of diazepam (DZ). The low maintenance dose of DZ (5 mg/kg twice daily) was selected as more closely associated with its anxiolytic effects than the higher treatment doses previously used to study BZ dependence. Food-restricted rats were trained to press a lever for food reinforcement under a FR20 schedule of reinforcement prior to the start of DZ administration. Acute… Expand
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