Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice

@article{Hasue2005IncreasedST,
  title={Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout mice},
  author={Fumio Hasue and Tomoyuki Kuwaki and Yaz Y. Kisanuki and Masashi Yanagisawa and Megumi Shimoyama},
  journal={Neuroscience},
  year={2005},
  volume={130},
  pages={349-358}
}
Endothelin-1 (ET-1) exists in endothelial cells as well as a variety of other cell types. The presence of ET-1 and its receptors in neurons suggests its possible role as a neurotransmitter and/or neuromodulator. Studies utilizing exogenous ET-1 have suggested that ET-1 affects pain transmission. This study was designed to examine the possible role(s) of neuronal ET-1 in pain processing. We produced neuron-specific ET-1 knockout mice using the Cre/loxP system with a synapsin I promoter and… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Pharmacological characterization of acute pain behavior produced by application of endothelin-1 to rat sciatic nerve
TLDR
It is established that acute pain behavior induced by ET-1 applied to rat sciatic nerve is dose-dependent, subject to desensitization with repeat application, reversible, and likely caused by actions within the intraneural compartment. Expand
Expression and Localization of Endothelin Receptors: Implications for the Involvement of Peripheral Glia in Nociception
TLDR
Analysis of distribution of ETAR and ETBR in dorsal root ganglia and peripheral nerve of the rat, rabbit, and monkey indicates that ETs can have direct, nociceptive effects on the peripheral sensory nervous system and that peripheral glia may be directly involved in signaling nocICEptive events in peripheral tissues. Expand
Local Injection of Endothelin-1 Produces Pain-Like Behavior and Excitation of Nociceptors in Rats
TLDR
It is demonstrated that subcutaneous administration of ET-1 to the rat plantar hindpaw produces pain-like behavior and selective excitation of nociceptive fibers through activation of ETAreceptors. Expand
Role of endothelin-1 in stress response in the central nervous system.
TLDR
It is shown that CNS responses to emotional and physical stressors are differentially affected in heterozygous ET-1-knockout mice, which exhibited diminished aggressive and autonomic responses toward intruders but responded to restraint-induced stress more intensely than wild-type mice. Expand
Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury
TLDR
A new endogenous analgesic circuit is mapped, in which ETB receptor activation induces the release of β-endorphin from keratinocytes and the activation of G-protein-coupled inwardly rectifying potassium channels (GIRKs) linked to opioid receptors on nociceptors. Expand
Behavioral signs of acute pain produced by application of endothelin‐1 to rat sciatic nerve
TLDR
Prior and co-administration of BQ-123, an endothelin-A (ETA) receptor antagonist, also blocked ET-1-induced hindpaw flinching establishing that pain behavior induced by ET- 1 application to rat sciatic nerve is ETA receptor mediated. Expand
ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain.
TLDR
Results indicate that the selective blockade of endothelin ET(A) receptors results in an attenuation of tactile allodynia in the streptozotocin-treated rat, a common complication of diabetic neuropathy. Expand
Endothelin-1 in periaqueductal gray area of mice induces analgesia via glutamatergic receptors
TLDR
It is suggested that the activation of NMDA glutamatergic receptors in the PAG area may be a necessary step for ET‐1 induced antinociception. Expand
Histochemical studies on endothelin and the endothelin-A receptor in the hypothalamus.
TLDR
It is concluded that ET, one of the "brain-vascular peptides," has a close relationship with the catecholamine neuron system in the brain and may regulate neurotransmission in the hypothalamic region. Expand
PHYSIOLOGICAL ROLE OF BRAIN ENDOTHELIN IN THE CENTRAL AUTONOMIC CONTROL: FROM NEURON TO KNOCKOUT MOUSE
TLDR
Endothelin in the brain is thought to be deeply involved in the central autonomic control and consequent cardiorespiratory homeostasis, possibly as a neuromodulator or a hormone that functions locally in an autocrine/paracrine manner or widely through delivery by the cerebrospinal fluid (CSF). Expand
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5
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