Increased sensitivity of lymphocyte Δ1pyrroline-5-carboxylate reductase to inhibition by proline with transformation

THE mitogen-induced transformation of resting lymphocytes to proliferating blast forms is associated with a marked increase in amino-acid uptake1, protein synthesis2 and enzyme activities3. There is little information, however, on the effect of transformation on enzymes of amino-acid metabolism. We therefore examined the biosynthetic and degradative enzymes… CONTINUE READING