Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract

@article{Young2005IncreasedSO,
  title={Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract},
  author={Shun-Chieh Young and Chau-Jong Wang and Jeng-dong Hsu and J Hsu and F S Chou},
  journal={Archives of Toxicology},
  year={2005},
  volume={80},
  pages={319-327}
}
Piper betel leaves (PBL) are used in Chinese folk medicine for the treatment of various disorders. PBL has the biological capabilities of de-toxication, anti-oxidation and anti-mutation. In this study we first examined the effect of PBL extract on the activity of Glutathione S-transferase (GST) isoforms, and found that it inhibited total GST and the α class of GST (GSTA), but not the π class of GST (GSTP), and the μ class of GST (GSTM), activity in Hep G2 cells. RT-PCR results verified a… CONTINUE READING
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