Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.

  title={Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.},
  author={Gilles Sansig and Trevor J Bushell and Vernon R. J. Clarke and Andrei Rozov and Nail Burnashev and Ch. Portet and Fabrizio Gasparini and Markus Schmutz and Klaus Klebs and Ryuichi Shigemoto and Peter Josef Flor and Rainer Kuhn and Thomas Kn{\"o}pfel and Martina Schroeder and David R. Hampson and Valerie J. Collett and Chuan-sheng Zhang and Robert M. Duvoisin and Graham L Collingridge and Herman van der Putten},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 22},
To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7(-/-)). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals aged 12 weeks and older, subthreshold doses of these drugs induced seizures in mGluR7(-/-), but not in mGluR7(+/-), mice. PTZ-induced seizures were inhibited by three standard… CONTINUE READING
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Elevated levels of group III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate

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