Increased seizure susceptibility and cortical malformation in beta-catenin mutant mice.

@article{Campos2004IncreasedSS,
  title={Increased seizure susceptibility and cortical malformation in beta-catenin mutant mice.},
  author={Victor E Campos and Mengyuan Du and Yuqing Li},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={320 2},
  pages={606-14}
}
Beta-catenin has been implicated in epilepsy because of its altered post seizure expression and the role of Wnt2 signaling in autism. To determine beta-catenin's role in seizure susceptibility, we injected penetylenetetrazol intraperitoneally in beta-catenin cerebral cortex- and hippocampus-specific knockout mice. We then analyzed the latency, number, and duration of four phases of seizure behaviors: (I) non-seizure activity, (II) myoclonic jerks, (III) generalized clonic seizures, and (IV… CONTINUE READING

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