Increased seizure duration in mice lacking aquaporin-4 water channels.

  title={Increased seizure duration in mice lacking aquaporin-4 water channels.},
  author={Devin K. Binder and Xiaoming Yao and Alan S Verkman and Geoffrey T. Manley},
  journal={Acta neurochirurgica. Supplement},
Aquaporins are intrinsic membrane proteins involved in water transport in fluid-transporting tissues. In the brain, aquaporin-4 (AQP4) is expressed widely by glial cells, but its function is unclear. Extensive basic and clinical studies indicate that osmolarity affects seizure susceptibility, and in our previous studies we found that AQP4 -/- mice have an elevated seizure threshold in response to the chemoconvulsant pentylenetetrazol. In this study, we examined the seizure phenotype of AQP4… CONTINUE READING

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100 mA), whereas the AQP4 / mouse had a much longer seizure (37 seconds) (stimulation threshold: 170 mA)

  • C Dalloz, R Sarig, +10 authors threshold an AQP4 mouse . The WT mouse had an 11-second seiz stimulation
  • Behavioral arrest was observed in both animals…
  • 2003
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The molecular basis of water transport in the brain

  • Amiry-MoghaddamM, OP Ottersen
  • Nat Rev Neurosci
  • 2003
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