Increased secretion of hyperimmune antibodies following lipopolysaccharide stimulation of CD40-activated human B cells in vitro.

@article{Dumont2009IncreasedSO,
  title={Increased secretion of hyperimmune antibodies following lipopolysaccharide stimulation of CD40-activated human B cells in vitro.},
  author={Nellie Dumont and {\'E}ric Aubin and Dominic Paquin Proulx and R{\'e}al Lemieux and Ren{\'e}e Bazin},
  journal={Immunology},
  year={2009},
  volume={126 4},
  pages={588-95}
}
Human B cells can be cultured ex vivo for a few weeks, following stimulation of the CD40 cell surface molecule in the presence of recombinant cytokines such as interleukin-4 (IL-4). However, attempts to produce polyclonal antigen-specific human antibodies by in vitro culture of human B cells obtained from immunized donors have not been successful. It has been shown in mice that lipopolysaccharide (LPS) is a potent mitogen for B cells and plays an important role in the generation of antigen… CONTINUE READING

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This increased differentiation could be explained by the observation that LPS - stimulated human B cells were induced to secrete higher amounts of IL-6 , a pleiotropic cytokine well - known for its B - cell differentiation activity .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
It has been shown in mice that lipopolysaccharide ( LPS ) is a potent mitogen for B cells and plays an important role in the generation of antigen - specific antibody responses .
This increased differentiation could be explained by the observation that LPS - stimulated human B cells were induced to secrete higher amounts of IL-6 , a pleiotropic cytokine well - known for its B - cell differentiation activity .
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