Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.

@article{Vandenbroucke1994IncreasedRO,
  title={Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.},
  author={Jan P. Vandenbroucke and Ted Koster and Ernest Bri{\"e}t and Pieter H. Reitsma and Rogier M. Bertina and Frits R Rosendaal},
  journal={Lancet},
  year={1994},
  volume={344 8935},
  pages={1453-7}
}
We investigated whether the occurrence of venous thrombosis in young women who use oral contraceptives might be explained by the factor V Leiden mutation, which leads to resistance to activated protein C and enhances susceptibility to thrombosis. We compared 155 consecutive premenopausal women, aged 15 to 49, who had developed deep venous thrombosis in the absence of other underlying diseases, with 169 population controls. The risk of thrombosis among users of oral contraceptives was increased… CONTINUE READING
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