Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease.

@article{Andrieu1990IncreasedRO,
  title={Increased risk of secondary acute nonlymphocytic leukemia after extended-field radiation therapy combined with MOPP chemotherapy for Hodgkin's disease.},
  author={J M Andrieu and Norbert Ifrah and Catherine Payen and Jacques Fermanian and Yvan Coscas and Georges Flandrin},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1990},
  volume={8 7},
  pages={1148-54}
}
The purpose of this study was to evaluate the influence of the number of mechlorethamine, vincristine, procarbazine, and prednisolone (MOPP) cycles and the extent of irradiation on the risk of secondary acute nonlymphocytic leukemia (SANLL) after a single combined treatment for Hodgkin's disease (HD). Between April 1972 and May 1980, 462 patients with HD clinical stage (CS) I, II, and III were prospectively treated with three or six cycles of MOPP and supra- and/or infradiaphragmatic… CONTINUE READING