Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.

@article{ElOmar2003IncreasedRO,
  title={Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.},
  author={Emad M. El-Omar and Charles S. Rabkin and Marilie Denise Gammon and Thomas L. Vaughan and Harvey A. Risch and Janet B. Schoenberg and Janet L. Stanford and Susan Taylor Mayne and James Jerome Goedert and William J. Blot and Joseph F. Jr. Fraumeni and Wong-Ho Chow},
  journal={Gastroenterology},
  year={2003},
  volume={124 5},
  pages={1193-201}
}
BACKGROUND & AIMS Genetic variations in proinflammatory and anti-inflammatory cytokine genes influence individual response to carcinogenic exposures. Polymorphisms in interleukin (IL)-1 beta and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer. The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite. METHODS We assessed polymorphisms of… CONTINUE READING
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