Increased risk of myocardial infarction as first manifestation of ischaemic heart disease and nonselective nonsteroidal anti-inflammatory drugs.

@article{Hawkey2006IncreasedRO,
  title={Increased risk of myocardial infarction as first manifestation of ischaemic heart disease and nonselective nonsteroidal anti-inflammatory drugs.},
  author={Christopher John Hawkey and G M Hawkey and Sarah Everitt and Maeve M Skelly and William A Stack and David Gray},
  journal={British journal of clinical pharmacology},
  year={2006},
  volume={61 6},
  pages={730-7}
}
AIMS Selective cyclooxygenase (COX)-2 inhibitors have recently been implicated as enhancing risk of myocardial infarction (MI). Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are also effective COX-2 inhibitors, so we investigated the hypothesis that they too increase risk of MI. METHODS We conducted a case-control study with direct structured interview of cases and controls. Cases were all subjects (N = 205) with a first nonfatal MI who had no previously recognized cardiovascular… CONTINUE READING