Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.


BACKGROUND AND METHODS Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. RESULTS Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. CONCLUSIONS The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.

DOI: 10.1016/j.ejca.2012.01.038
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@article{Cote2012IncreasedRO, title={Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium.}, author={Michele L. Cote and Mei Liu and Stefano Bonassi and Monica Neri and Ann Grossbart Schwartz and David C. Christiani and Margaret R. Spitz and Joshua E. Muscat and Gad Rennert and Katja K. H. Aben and Angeline S. Andrew and Vladim{\'i}r Bencko and Heike Bickeb{\"{o}ller and Paolo Boffetta and Paul Brennan and Hermann Brenner and Eric J Duell and Eleon{\'o}ra Fabi{\'a}nov{\'a} and John K. Field and Lenka For{\'e}tova and S\oren Friis and Curtis C. Harris and Ivana Holc{\'a}tov{\'a} and Yun-Chul Hong and Dolores Isla and Vladim{\'i}r Janout and Lambertus A Kiemeney and Chikako Kiyohara and Qing Lan and Philip Lazarus and Jolanta Lissowska and Lo{\"{i}c Le Le Marchand and Dana Mateş and Keitaro Matsuo and Jos{\'e} Ignacio Mayordomo and John R McLaughlin and Hal Morgenstern and Heiko M{\"{u}eller and Irene Orlow and Bernard J H Park and Mila Pinchev and Olaide Y. Raji and Hedy S. Rennert and P{\'e}ter Rudnai and Adeline L H Seow and Isabelle Stucker and Neonila Szeszenia-Dąbrowska and M. Dawn Teare and Anne Tj\onnelan and Donatella Ugolini and Henricus F. M. van der Heijden and Erich H. Wichmann and John K. Wiencke and Penella Woll and Ping Yang and David G. Zaridze and Zuo-Feng Zhang and Carol Jean Etzel and Rayjean J Hung}, journal={European journal of cancer}, year={2012}, volume={48 13}, pages={1957-68} }