Increased risk of large-bowel cancer in Crohn's disease with colonic involvement

@article{Ekbom1990IncreasedRO,
  title={Increased risk of large-bowel cancer in Crohn's disease with colonic involvement},
  author={Anders Ekbom and Hans-Olov Adami and Charles G. Helmick and Matthew M. Zack},
  journal={The Lancet},
  year={1990},
  volume={336},
  pages={357-359}
}
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702 Citations
Highly Influential Citations
25
Background Citations
167
Methods Citations
6
Results Citations
21

702 Citations

Risk of colorectal cancer in Crohn's disease patients with colonic involvement and stenosing disease in a population-based cohort from Hungary.
TLDR
The risk of CRC in CD patients presenting with or developing a stenotic lesion in the colon is high even after a short disease duration, suggesting the need for careful surveillance.
Crohn's disease and colorectal cancer.
TLDR
There is a statistical excess risk of developing colorectal cancer in patients who develop their Crohn's disease at a young age of onset (less than 30 years of age).
Crohn's disease and cancer risk (Denmark)
TLDR
Only for small intestinal cancer was a significantly elevated risk found among these patients hospitalized with Crohn's disease, and it was not detectable in the overall risk estimate for colorectal cancer.
Risk factors for small bowel cancer in Crohn's disease
TLDR
Pro proximal small bowel disease, 6-mercaptopurine use, and hazardous occupations are associated with cancer of the small bowel in patients with Crohn's disease and can be added to the list of suspected risk factors.
Risk factors for small bowel cancer in Crohn's disease
  • B. Lashner
  • Medicine
    Digestive diseases and sciences
  • 1992
TLDR
Pro proximal small bowel disease, 6-mercaptopurine use, and hazardous occupations are associated with cancer of the small bowel in patients with Crohn's disease and can be added to the list of suspected risk factors.
Crohn ' s disease and colorectal cancer Results COLORECTAL CANCERS
TLDR
There is a statistical excess risk of developing colorectal cancer in patients who develop their Crohn's disease at a young age of onset (less than 30 years of age), which is 20 times that expected in the general population.
Intestinal cancer risk and mortality in patients with Crohn's disease.
Anal and rectal cancer in Crohn's disease
TLDR
During 1987–2000 rectal or anal cancer was diagnosed in 335 patients in Sweden (153 males, 182 females) and approximately 3 Crohn patients per million inhabitants were diagnosed every year during that time period which is 1% of the total number of cases.
Surgical Options for Neoplasia Complicating Crohn’s Disease of the Large Intestine
TLDR
Individuals with Crohn’s disease of the large intestine develop colorectal cancer at an increased rate compared to the general population, and this appears to develop via a pathway that deviates from the well characterized adenoma-carcinoma sequence of sporadic coloreCTal cancer.
Colorectal Cancer and Crohn’s Colitis: Clinical Implications From 313 Surgical Patients
TLDR
Crohn’s colitis patients who require surgery are at higher risk for developing CRC, particularly those whose disease duration is >10  years, have distal localization, age at diagnosis was <40 years, and have penetrating disease.
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References

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TLDR
Cancer morbidity has been evaluated in a series of 513 patients with Crohn's disease under long-term review between 1944-76 and there was no excess of tumours at any site outside the digestive system.
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TLDR
The incidence of cancer in Crohn's disease has been evaluated in 473 patients admitted to Rigshospitalet during the period 1 April 1964 to 1 January 1983 and found no increased risk of developing cancer inside the gastrointestinal tract compared with a background population matched for age, sex, and calendar time.
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TLDR
The risk of cancer in Crohn's disease was not significantly increased in the two existing population studies, including the present one, and a review of the literature showed conflicting results with regard to cancer risk.
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The results indicate that some of the patients with Crohn's disease run a more serious course with continuing symptoms despite of medical treatment and frequent surgical interventions.
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The authors estimated cancer risk among 579 patients hospitalized with Crohn's disease between 1960–1976 by calculating the ratios of observed number of cancers (O) in our hospital sample to the…
Crohn's disease and cancer.
Abstract A follow-up study of 449 patients with Crohn's enteritis, enterocolitis or colitis showed the incidence of colonorectal cancer to be 20 times greater in these cases than in a control…
Epidemiologic aspects of Crohn's disease: a population based study in Olmsted County, Minnesota, 1943-1982.
TLDR
Overall, the natural history of Crohn's disease in the community may be milder than that reported for patients at referral centres, as over half of all patients had no complications and only a third required surgery for Crohn’s disease.
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TLDR
It is concluded that present evidence does not establish an increased risk of malignancy in colonic Crohn's disease.
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