Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases.

@article{Lordick2006IncreasedRO,
  title={Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases.},
  author={Florian Lordick and Hans Geinitz and Joerg Theisen and Andreas Sendler and Mario Sarbia},
  journal={International journal of radiation oncology, biology, physics},
  year={2006},
  volume={64 5},
  pages={1295-8}
}
PURPOSE To assess the rate of severe bowel complications during treatment with the anti-vascular endothelial growth factor monoclonal antibody bevacizumab. METHODS AND MATERIALS We performed a retrospective evaluation of bevacizumab-associated severe intestinal adverse events from our institutional database. RESULTS A total of 33 patients started treatment with bevacizumab at our institution during the first 6 months after its approval in Germany. Three patients (9%) presented with severe… CONTINUE READING

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