Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1.

@article{Sun1999IncreasedRO,
  title={Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1.},
  author={Zongtang Sun and Peixin Lu and Mitchell H. Gail and David Y Pee and Qian Zhang and Lihua Ming and Jiyao Wang and Guoting Liu and Yun-zhong Wu and Y Zhu},
  journal={Hepatology},
  year={1999},
  volume={30 2},
  pages={379-83}
}
We followed 145 men with chronic hepatitis B virus (HBV) hepatitis for 10 years to determine whether exposure to aflatoxin, or concomitant exposure to hepatitis C virus (HCV), or family history of hepatocellular carcinoma (HCC) increased the risk of developing HCC. We collected 8 monthly urine samples before beginning follow-up and pooled them to detect aflatoxin metabolite M1 (AFM1). AFM1 was detected in 78 (54%) of the subjects. The risk of HCC was increased 3.3-fold (with a 95% confidence… CONTINUE READING

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