Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype.

@article{Perfumo2006IncreasedRO,
  title={Increased risk of colorectal adenomas in Italian subjects carrying the p53 PIN3 A2-Pro72 haplotype.},
  author={Chiara Perfumo and Luigina Bonelli and Paola Menichini and Alberto Inga and Viviana Gismondi and Enrico Ciferri and Pierluigi Percivale and Giovanna Bianchi Scarr{\`a} and Sabina Nasti and Gilberto Fronza and Liliana Varesco},
  journal={Digestion},
  year={2006},
  volume={74 3-4},
  pages={228-35}
}
BACKGROUND Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. AIM To explore the impact of the p53 PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer. METHODS One hundred and eighty-four colorectal tumor patients (124 with adenomas and 60 with adenocarcinoma) and 188 controls (42 subjects… CONTINUE READING

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