Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.

@article{Ichimura2004IncreasedRO,
  title={Increased risk of bladder cancer associated with a glutathione peroxidase 1 codon 198 variant.},
  author={Yasushi Ichimura and Tomonori Habuchi and Norihiko Tsuchiya and Lizhong Wang and Chikara Oyama and Kazunari Sato and Hiroyuki Nishiyama and Osamu Ogawa and Tetsuro Kato},
  journal={The Journal of urology},
  year={2004},
  volume={172 2},
  pages={728-32}
}
PURPOSE The glutathione peroxidase 1 gene (GPX1) and the manganese superoxide dismutase gene (MnSOD) encode the main antioxidant enzymes that detoxify endogenous reactive oxygen species involved in carcinogenesis. Polymorphisms of GPX1 and MnSOD genes, and the risk of transitional cell cancer of the bladder were tested. MATERIALS AND METHODS Genotypes of the leucine (Leu) to proline (Pro) polymorphism at codon 198 of GPX1, the alanine (Ala) to Valine (Val) polymorphism in exon 2 and the… CONTINUE READING

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