Increased risk for demyelinating diseases in patients with inflammatory bowel disease.

  title={Increased risk for demyelinating diseases in patients with inflammatory bowel disease.},
  author={Gauree Gupta and Joel M. Gelfand and James D Lewis},
  volume={129 3},
BACKGROUND & AIMS Reports of multiple sclerosis (MS), demyelination, and optic neuritis (ON) associated with anti-tumor necrosis factor alpha therapy resulted in warnings on prescribing instructions for infliximab, etanercept, and adalimumab. However, the underlying relationship between IBD and these neurologic conditions has not been established. METHODS We performed a retrospective cohort study and a retrospective cross-sectional study using 1988 to 1997 data from the General Practice… CONTINUE READING


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