Increased responsiveness to the hyperglycemic, hyperglucagonemic and hyperinsulinemic effects of circulating norepinephrine in ob/ob mice

@article{Liang2001IncreasedRT,
  title={Increased responsiveness to the hyperglycemic, hyperglucagonemic and hyperinsulinemic effects of circulating norepinephrine in ob/ob mice},
  author={Y. Liang and A. Cincotta},
  journal={International Journal of Obesity},
  year={2001},
  volume={25},
  pages={698-704}
}
OBJECTIVE: Several studies have implicated increased sympathetic tone as a contributing factor to the hyperglycemia and hyperglucagonemia of ob/ob mice. However, the responsiveness of plasma glucose, insulin and glucagon to circulating norepinephrine (NE) in ob/ob vs normal lean mice has never been described. Therefore, the present study investigated the effect of a 15 min intravenous NE infusion (1 pmol/min/g) on plasma glucose, insulin and glucagon in anesthetized lean, ob/ob, ob/ob… Expand
Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice.
TLDR
Data suggest that systemic sympatholytic dopaminergic therapy that attenuates hyperglycemia and hyperlipidemia improves islet function in ob/ob mice by improving aberrations in the beta cell's glucose-sensing apparatus, enhancing insulin storage and/or retention, and stabilizing hyperplasia, thus reducing basal insulin levels. Expand
Bromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes
Bromocriptine is a sympatholytic D2-dopamine agonist that has been approved for the treatment of type 2 diabetes. Based on animal and human studies, timed bromocriptine administration within 2 h ofExpand
Impaired Ca2+ Signaling in β-Cells Lacking Leptin Receptors by Cre-loxP Recombination
TLDR
It is observed that β-cells lacking leptin signaling in this model are capable of properly metabolizing glucose, but show impaired intracellular Ca2+ oscillations and lack of synchrony within the islets in response to glucose, display reduced response to tolbutamide and exhibit morphological abnormalities including increased autophagy. Expand
The Effect of Long-Term Intranasal Serotonin Treatment on Metabolic Parameters and Hormonal Signaling in Rats with High-Fat Diet/Low-Dose Streptozotocin-Induced Type 2 Diabetes
TLDR
The elevation of the brain serotonin level may be regarded as an effective approach to treat type 2 diabetes mellitus and its complications. Expand
The effect of 2-month bromocriptine treatment on the activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes
TLDR
Investigation of the effect of BC treatment on the functional activity of the adenylyl cyclase signaling system (ACSS) in the myocardium and testes of male rats suffering from type 2 diabetes induced by high-fat diet and administration of streptozotocin found that prolonged BC treatment restored thefunctional activity of ACSS. Expand
Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells.
TLDR
Using cultured hepatic stellate cells, it is shown that the sympathetic neurotransmitters, norepinephrine and neuropeptide Y, markedly stimulate the proliferation of activated, myofibroblastic, hepaticStellates, and directly modulate the phenotype of hepatic Stellate Cells. Expand
Sympathetic nervous system regulation of liver repair.
  • J. Oben, A. Diehl
  • Biology, Medicine
  • The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
  • 2004
TLDR
Evidence that the sympathetic nervous system regulates liver repair by modulating the phenotypes of hepatic stellate cells, the liver's principal fibrogenic cells, and hepatic epithelial progenitors is reviewed, suggesting that HSCs may be targets for SNS neurotransmitters. Expand
Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells.
TLDR
DHA may protect against obesity-associated inflammation and colon carcinogenesis by suppressing insulin-induced activation of SREBP-1 and expression of COX-2 through up-regulation of SIRT1. Expand
Interaction of Insulin Hormone with Microalbuminuria and Blood Pressure in Type 2 Diabetic Patients.
TLDR
The results of this study showed that patients with diabetic of both male and female have significant elevation in insulin hormone levels, insulin resistance, fasting blood glucose (FBG) and microalbuminuria than control group. Expand
Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases
TLDR
The changes in the brain signaling systems play an important role in etiology and pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), and their restoration at the early stages can be regarded as a promising way to treat and prevent these diseases and their complications. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 50 REFERENCES
Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse
TLDR
The results suggest that altered peripheral responses to sympathetic stimuli contribute to stress-induced hyperglycemia in ob/ob mice, and raise the possibility that altered sympathetic function is an etiologic factor in development of diabetes in these animals. Expand
Increased responsiveness of ventromedial hypothalamic neurons to norepinephrine in obese versus lean mice: relation to the metabolic syndrome.
TLDR
The present results suggest that increased VMH responsiveness to NE contributes to the pathophysiology of the obese-hyperglycemic state and is part of the endogenous neurophysiology of obese- hyperglycemic ob/ob mice. Expand
Dopamine agonist treatment ameliorates hyperglycemia, hyperlipidemia, and the elevated basal insulin release from islets of ob/ob mice.
TLDR
The results demonstrate that dopamine agonist treatment improves basal insulin release in ob/ob mice and this effect may be mediated, in part, by a reduction of hyperglycemia and hyperlipidemia. Expand
Adrenoceptor-mediated control of glucose homeostasis in obese hyperglycaemic (ob/ob) mice.
TLDR
The results indicate abnormalities of adrenoceptor mechanisms in ob/ob mice which favour impaired glucose homeostasis. Expand
Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice.
  • V. Boundy, A. Cincotta
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2000
TLDR
Changes in hypothalamic adrenergic receptors support a role for increased hypothalamic NE activity in the development of the metabolic syndrome of ob/ob mice. Expand
Chronic infusion of norepinephrine into the VMH of normal rats induces the obese glucose-intolerant state.
  • A. Cincotta, S. Luo, +4 authors P. Scislowski
  • Chemistry, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2000
TLDR
Increases in VMH NE activity that are common among obese insulin-resistant animal models can cause the development of this obese glucose-intolerant (metabolic) syndrome. Expand
Diminished epinephrine excretion in genetically obese (ob/ob) mice and monosodium glutamate-treated rats.
  • F. S. Leigh, L. N. Kaufman, J. Young
  • Medicine
  • International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
  • 1992
TLDR
Findings indicate that secretion of Epi by the adrenal medulla is diminished, but is normally responsive to stimulation in these two models of animals obesity, and are consistent with accumulating evidence of a functional impairment in adrenalmedullary secretion in animal and human obesity. Expand
Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse.
TLDR
Data indicate that diminished SNS activity in ob/ob mice may be an additional factor contributing to the defective thermogenesis characteristic of these animals. Expand
Dopaminergic Agonists Normalize Elevated Hypothalamic Neuropeptide Y and Corticotropin-Releasing Hormone, Body Weight Gain, and Hyperglycemia in ob/ob Mice
TLDR
It is suggested that dopaminergic D1/D2 receptor coactivation may improve hyperphagia, hyperglycemia, and obesity in the ob/ob mouse, in part, by normalizing elevated levels of both NPY and CRH. Expand
Chronic Ventromedial Hypothalamic Infusion of Norepinephrine and Serotonin Promotes Insulin Resistance and Glucose Intolerance
TLDR
These findings demonstrate for the first time the differential and, more importantly, interactive effects of increased VMH NE and 5-HT in producing hyperinsulinemia, insulin resistance and glucose intolerance. Expand
...
1
2
3
4
5
...