Increased responsiveness to glucoregulatory effect of opiates in obese-diabetic ob/ob mice

@article{Bailey1987IncreasedRT,
  title={Increased responsiveness to glucoregulatory effect of opiates in obese-diabetic ob/ob mice},
  author={Clifford J Bailey and Peter Raymond Flatt},
  journal={Diabetologia},
  year={1987},
  volume={30},
  pages={33-37}
}
Plasma glucose and insulin responses to opiate receptor stimulation and antagonism were determined in 12–14 week old lean and obese-diabetic Aston ob/ob mice. The opiate receptor antagonist naloxone (1 mg/kg intraperitoneally) rapidly and transiently raised glucose and suppressed insulin concentrations in lean mice, and produced qualitatively similar but more protracted responses in ob/ob mice. Selective stimulation of μ- and δ-opiate receptors using the enkephalin analogues Tyr-D-Ala-Gly-MePhe… CONTINUE READING