Increased reproductive success of MHC class II heterozygous males among free-ranging rhesus macaques

@article{Sauermann2001IncreasedRS,
  title={Increased reproductive success of MHC class II heterozygous males among free-ranging rhesus macaques},
  author={Ulrike Sauermann and Peter N{\"u}rnberg and Fred B. Bercovitch and John D. Berard and Andrea Trefilov and Anja Widdig and Matt J. Kessler and Joerg Schmidtke and Michael Krawczak},
  journal={Human Genetics},
  year={2001},
  volume={108},
  pages={249-254}
}
Gene conversion and balancing selection have been invoked to explain the ubiquitous diversity of the antigen-presenting proteins encoded in the vertebrate major histocompatibility complex (MHC). In the present study, direct evidence for over-dominant selection promoting MHC diversity in primates is provided by the observation that, in a large free-ranging population of rhesus macaques, males heterozygous at MHC class II locus Mamu-DQB1 sired significantly more offspring than homozygotes (the… CONTINUE READING

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Statistical inference from DNA evidence

M Krawczak
1999

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