Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes.

@article{Nmeth2009IncreasedRW,
  title={Increased renoprotection with ACE inhibitor plus aldosterone antagonist as compared to monotherapies--the effect on podocytes.},
  author={Zal{\'a}n N{\'e}meth and G. Kokeny and M. God{\'o} and M. M{\'o}zes and L. Rosivall and M. Gro{\ss} and E. Ritz and P. Hamar},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2009},
  volume={24 12},
  pages={
          3640-51
        }
}
  • Zalán Németh, G. Kokeny, +5 authors P. Hamar
  • Published 2009
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • BACKGROUND Blockade of the renin-angiotensin-aldosterone system (RAAS) does not completely prevent progression of renal disease. Mineralocorticoid receptor blockade provides additional renoprotection over ACE-inhibition monotherapy. We examined the mechanisms underlying superior renoprotection in the subtotal nephrectomy (SNX) model. METHODS Sprague-Dawley rats were randomized into six groups: (1) sham-op, (2) SNX without treatment, (3) SNX + quinapril (Q), (4) SNX + spironolactone (S), (5… CONTINUE READING
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