Increased renal production of transforming growth factor-beta1 in patients with type II diabetes.

@article{Sharma1997IncreasedRP,
  title={Increased renal production of transforming growth factor-beta1 in patients with type II diabetes.},
  author={Kumar Sharma and Fuad N. Ziyadeh and Basem Alzahabi and Tracy A McGowan and Shiv Kapoor and Blaz Kurnik and Peter B Kurnik and Lawrence S. Weisberg},
  journal={Diabetes},
  year={1997},
  volume={46 5},
  pages={854-9}
}
Diabetic nephropathy is a common complication in patients with either type I or type II diabetes. The pathogenesis of diabetic nephropathy is thought to involve both metabolic and vascular factors leading to chronic accumulation of glomerular mesangial matrix. In this context, both transforming growth factor-beta (TGF-beta) and endothelin may contribute to these processes. To determine if diabetic patients demonstrate increased renal production of TGF-beta and endothelin, aortic, renal vein… CONTINUE READING

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