Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat.

@article{Knight2007IncreasedRP,
  title={Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat.},
  author={Sarah Knight and Harold G Snellen and Michael H. Humphreys and Chris Baylis},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 2},
  pages={F655-9}
}
Normal rat pregnancy is characterized by plasma volume expansion due to renal sodium retention and is associated with a blunted response to natriuretic stimuli, such as atrial natriuretic peptide (ANP). ANP signals via cGMP, and phosphodiesterases (PDE) inactivate cGMP and terminate the natriuretic response. We previously reported that increased medullary PDE-5 activity occurs in rat pregnancy, which may be the mechanism of the blunted natriuretic effect of ANP. Here, we used anesthetized 16… CONTINUE READING

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