Increased renal metabolism in diabetes. Mechanism and functional implications.

  title={Increased renal metabolism in diabetes. Mechanism and functional implications.},
  author={Anna K{\"o}rner and Ann Christine Ekl{\"o}f and Gianni E Celsi and Anita C. Aperia},
  volume={43 5},
The coupling between the Na+/glucose cotransporter and Na(+)-K(+)-ATPase (NKA) described for epithelial cells (1) prompted us to study in rats with streptozocin-induced diabetes the effect of increased tubular glucose load on tubular Na+ reabsorption, NKA-dependent O2 consumption (QO2), and NKA activity. Filtered glucose is mainly reabsorbed in the proximal tubuli via the phlorizin-sensitive Na+/glucose cotransporter. In this study, the diabetic rats had a significantly higher renal blood flow… CONTINUE READING


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