Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats.

@article{Cowley2001IncreasedRE,
  title={Increased renal expression of monocyte chemoattractant protein-1 and osteopontin in ADPKD in rats.},
  author={Benjamin Cowley and Sharon D Ricardo and Shizuko Nagao and Jeffrey R. Diamond},
  journal={Kidney international},
  year={2001},
  volume={60 6},
  pages={2087-96}
}
BACKGROUND Human autosomal-dominant polycystic kidney disease (ADPKD) is variable in the rate of deterioration of renal function, with end-stage renal disease (ESRD) occurring in only approximately 50% of affected individuals. Evidence suggests that interstitial inflammation may be important in the development of ESRD in ADPKD. Han:SPRD rats manifest ADPKD that resembles the human disease. Homozygous cystic (Cy/Cy) rats develop rapidly progressive PKD and die near age 3 weeks. Heterozygous (Cy… CONTINUE READING
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