Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation

@article{Landau2009IncreasedRA,
  title={Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation},
  author={Daniel Landau and Renanah Eshet and Ariel Troib and Yotam Gurman and Yu Chen and Ralph Rabkin and Yoav Segev},
  journal={Endocrine},
  year={2009},
  volume={36},
  pages={126-134}
}
Growth hormone (GH) and IGF-I have been implicated in the pathogenesis of type I diabetic (DM) nephropathy. We investigated renal GH receptor (GHR) and IGF-type 1 receptor (IGF1R) signaling in an animal model of type I DM. Kidney tissue was examined for GHR and IGF1R key signaling molecules. GHR levels were unchanged and IGF-I mRNA levels were decreased in the diabetic group (D). Basal and GH stimulated phosphorylated (p-) JAK2 and STAT5 levels were similar in controls (C) and D. The levels of… CONTINUE READING
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